Research Innovations Development (Medical Imaging And Instrumentation)

(Medical Devices: Design, Developments, Evaluations, Innovations, Prototyping, Product Developments, Clinical Implementations And More)

Research (Multi Institutional, Collaborations):

Ultra High Field MRI (7T Human MRI Coil Imaging: Whole (Head, Body and Extremity) Imaging),

-> Whole Head Imaging: Multichannel (32) MRI Receive (Rx) Only Whole Head (Brain) Neck Insert For 20CH 7T TTT Transmit (Tx) Head (Brain) Coil Systems

-> Whole Body Imaging: Whole Body MRI (Torso, Abdomen, Including All Body Organs) RF Transmit (Tx) Receive (Rx) Coil Systems:

-> Musculoskeletal Imaging: Extremities (Shoulder, Elbow, Wrist, Hand (Fingers), Knee, Foot Ankle) MRI RF Tx Rx Coil Systems Imaging

-> Clinical Applications (T1, T2, T2*, Diffusion, SWI, NCE Angiography, fMRI, Perfusion, Spectroscopy, Dual Tune, Multi Organs And Emerging Applications) Developments: Healthy Brain Initiative, Transplantation (Arm Transplants), Plastic Surgery, Psychiatry, Alzheimer, Parkinson, Schizophrenia, Micro Vascularity, Multiple Scelerosis, Mild Cognitive Impairment, Depression, New Drug Development And Therapeutic Methods

-> RF And MR Safety (Temperature, RF Transparency And SAR) Measurement

Ultra Low Field MRI, Very And Extremely High Field MRI, Multimodal Imaging, Bio (Physiological) Signals And Systems With Real Time Monitoring, Brain Computer Interface Engineering, Learning (Big Data, Automation), OEM Technologies Research And Product Developments

Significance

Ultra High Field Magnetic Resonance Imaging

Medical Imaging (Radiology) & Instrumentation (Hardware, Software)

UHF MRI Research And Clinical Applications

Whole Head (Brain) Imaging:

Transmit and Receive Only Insert Array Head Coil (See more in "PEER Reviewed International Original Works")

Diffusion MRI

White Matter Hyperintensities MRI

Functional Magnetic Resonance Imaging (fMRI)

MR Angiography and ToFMRI

Whole Body Imaging:

Transmit and Receive Only Whole Body Coil

Raval, S.B., Santini, T., Wood, S., Krishnamurthy, N., Zhao, T., Ibrahim, T.S. “In-vivo (8x4) 32 channel Tx-Only Body Array for UHF MRI” in Proc. of The 23rd International Society of Magnetic Resonance in Medicine Annual Meeting, Toronto, Canada, May 2017, Proceedings, Invited Presentation

Raval, S.B., Zhao, T., Krishnamurthy, N., Zhao, Y., Wood, S., Bae, K-T., Ibrahim, T.S., “Initial Results: Ultra-High Field 32-ch Tx Body Array with Bright Centers” in Proc. of The 23rd International Society of Magnetic Resonance in Medicine Annual Meeting, Toronto, Canada, May 2015, Proceedings, Invited Presentation

Raval S.B., Zhao Y., Zhao, T., Krishnamurthy, N., Wood, S., Ibrahim, T.S. “7T Tx Body Coil with Rx-Only Insert: Preliminary Results” in Proc. of the 21st International Society of Magnetic Resonance in Medicine Annual Meeting, Utah, May 2013, Proceedings, Invited Presentation

See more in "PEER Reviewed International Original Works"

B1+ Field Distribution

In Vivo Imaging Data

Extremity Imaging

Transmit and Receive Only System

Raval, S. B., Zhao, T., Krishnamurthy, N., Santini, T., Britton, C., Gorantla, V. S., and Ibrahim, T. S. (2016) Ultra-high-field RF coil development for evaluating upper extremity imaging applications. NMR Biomed., 29: 1768–1779. doi: 10.1002/nbm.3582.

Raval S.B., Britton C.A., Zhao T., Krishnamurthy N., Santini T., Gorantla V.S., Ibrahim T.S. (2017) Ultra-high field upper extremity peripheral nerve and non-contrast enhanced vascular imaging. PLoS ONE 12(6): e0175629. https://doi.org/10.1371/journal.pone.0175629

See more in "PEER Reviewed International Original Works"

Specific Absorption Rate (SAR)

7T and 3T In Vivo Imaging

Diffusion Imaging

Vasculature Segmentation

PEER Reviewed National And International Original Works

Raval, S.B., Zhao, T., Krishnamurthy, N., Santini, T.R., Britton, C.A., Gorantla, V.S., and Ibrahim, T.S. (2016) Ultra-high-field RF coil development for evaluating upper extremity imaging applications. NMR Biomed., 29: 1768–1779. doi: 10.1002/nbm.3582.

Raval, S.B., Britton C.A., Zhao T., Krishnamurthy N., Santini T.R., Gorantla V.S., Ibrahim T.S. (2017) Ultra-high field upper extremity peripheral nerve and non-contrast enhanced vascular imaging. PLoS ONE 12(6): e0175629. https://doi.org/10.1371/journal.pone.0175629

Raval, S.B., Zhao, T., Zhao, Y., Ibrahim, T.S., Gorantla, V.S., Upper Extremity Ultra-High Field MR Imaging of Bilateral Hand Transplant Patient: Case Report (VCA), Plastic and Reconstructive Surgery: October 2015 - Volume 136 - Issue 4S - p 29–30, doi: 10.1097/01.prs.0000472310.97888

Raval, S.B., Zhao, T., Krishnamurthy, N., Ibrahim, T.S., Gorantla, V.S. “RF System for Ultra-High Field Upper Extremity Imaging” Plastic and Reconstructive Surgery, October 2015, 136 (4S), 81, doi: 10.1097/01.prs.0000472381.50361.f6

Raval, S.B., Zhao, T., Krishnamurthy, N., Ibrahim, T.S., Gorantla, V.S., “Exploring Peripheral Nerve, Macro and Micro-Vasculature Imaging Applications at Ultra-High Field MRI.” Plastic Reconstructive Surgery, October 2015,136 (4S), 20, doi: 10.1097/01.prs.0000472298.54825.5f.

Raval, S.B., Santini, T.R., Wood, S., Krishnamurthy, N., Zhao, T., Ibrahim, T.S. “In-vivo (8x4) 32 channel Tx-Only Body Array for UHF MRI” in Proc. of The 23rd International Society of Magnetic Resonance in Medicine Annual Meeting, Toronto, Canada, May 2017, Proceedings, Invited Presentation

Raval, S.B., Zhao, T., Krishnamurthy, N., Zhao, Y., Wood, S., Bae, K-T., Ibrahim, T.S., “Initial Results: Ultra-High Field 32-ch Tx Body Array with Bright Centers” in Proc. of The 23rd International Society of Magnetic Resonance in Medicine Annual Meeting, Toronto, Canada, May 2015, Proceedings, Invited Presentation

Raval, S.B., Zhao Y., Zhao, T., Krishnamurthy, N., Wood, S., Ibrahim, T.S. “7T Tx Body Coil with Rx-Only Insert: Preliminary Results” in Proc. of the 21st International Society of Magnetic Resonance in Medicine Annual Meeting, Utah, May 2013, Proceedings, Invited Presentation

Raval, S.B., Zhao, T., Krishnamurthy, N., Ibrahim, T.S., Gorantla, V.S., “Ultra-high Resolution Non-Contrast Vascular and Nerve Imaging for Graft Monitoring and Procedural Planning in Reconstructive Transplantation”, in Proc. Of the Military Health System Research Symposium (MHSRS), Florida, 2016, Proceedings, Invited Presentation

Raval, S.B., Zhao, T., Zhao, Y., Ibrahim, T.S., Gorantla, V.S., ”Non-contrast enhanced 7 tesla MR imaging for non-invasive monitoring of chronic rejection in reconstructive transplantation”, Vascularized Composite Allotransplantation, 2016, 3 (1-2), 21-22, Published online: 19 Oct 2016, doi:10.1080/23723505.2016.1233014, Invited Presentation

Raval, S.B., Zhao, T., Krishnamurthy, N., Ibrahim, T.S., Gorantla, V.S., “Ultra-high field upper extremity peripheral nerve and non-contrast vascular imaging at 7T tesla high resolution MRI”, in Proc. Of The 12thInternational hand and Composite Tissue Allotransplantation Society Annual Meeting, Philadelphia, April 2015. Proceedings, Invited Presentation

Raval, S.B., Zhao, T., Zhao, Y., Gorantla, V.S., Ibrahim, T.S., “Ultrahigh field(7T) magnetic resonance musculoskeletal imaging in upper extremity allotransplantation – first report in VCAMRI after upper extremity transplantation”, in Proc. Of The 12thInternational hand and Composite Tissue Allotransplantation Society Annual Meeting, Philadelphia, April 2015. Proceedings, Invited Presentation

Raval, S.B., Zhao, T., Krishnamurthy, N., Santini, T.R., Gorantla, V.S., Ibrahim, T.S., “RF System for Ultra-High Field Upper Extremity Imaging”, in 10th Biennial meeting at Center for Magnetic Resonance research, Minneapolis, Nov 2015.

Ercument, V.E., Sahin, H., Oksuz, S., Dong, L., Miller, M.R., Shojaati, G.,Wollstein, G., Chan, K.C., Sigal, I., Kostereva, N., Raval, S.B., Ibrahim, T.S., Goldberg, J.L., Benowitz, L., Schuman, J.S., Zor, F., Solari, M., Washington, K.M., Gorantla, V.S., “A Preclinical Swine Model for Whole Eyeball Transplantation - Planning and Procedural Aspects”. In Proc. Of The Plastic Surgery Research Council, November 2016 in Chicago, Illinois, USA, Proceedings, Invited Presentation

Zhao, Y., Zhao, T., Raval, S.B., Krishnamurthy, N., Zheng, H., Harris, C.T., Handler, W.B., Chronik, B.A., Ibrahim, T.S. (2015). Dual Optimization Method of RF and Quasi-Static Field Simulations for Reduction of Eddy Currents Generated on 7T RF Coil Shielding. Magnetic Resonance in Medicine, 74(5), 1461–1469. http://doi.org/10.1002/mrm.25424

Santini, T.R., Krishnamurthy, N., Wood, S., Raval, S.B., Zhao, Y., Fischetti, A., Koo, M., Aizenstein, H.J., Ibrahim, T.S., 64-channel Double-Octagon Tx Head Coil for 7T Imaging. Proc. Intl. Soc. Mag. Reson. Med. 25 (2017) 4308. doi: 10.1016/j.mri.2017.09.005.

Wood, S., Krishnamurthy, N., Santini, T., Raval, S.B., Farhat N., Holmes, J.A., et al. (2017) Design and fabrication of a realistic anthropomorphic heterogeneous head phantom for MR purposes. PLoS ONE 12(8): e0183168. https://doi.org/10.1371/journal.pone.0183168

Krishnamurthy, N., Stough, D., Zhao, T., Raval, S.B., Boada, F., Ibrahim, T.S., “B1+ and Coupling Variability of Transmit Head Coils and Arrays for Ultra-High Field MRI: Simulation Studies and Experiments. Proc. Intl. Soc. Mag. Reson. Med. 20. 2012

Santini, T.S., Kim, J-H., Wood, S., Krishnamurthy, N., Farhat, N., Maciel, C., Raval, S.B., Ibrahim, T.S. “A new RF Transmit Coil for Foot and Ankle Imaging at 7T MRI”. Magnetic resonance imaging 45, 1-6, January 2018 https://doi.org/10.1016/j.mri.2017.09.005 .

Gorantla, V.S., M.D., Ph.D., *Raval, S.B., M.S., Ph.D., Davis, M., M.D., Ibrahim, T.S., Ph.D., “Regenerative Medicine and Advanced Rehabilitation – Today and in Future”, “UHR NCE Vascular and Nerve Imaging for Graft Monitoring and Procedural Planning in Reconstructive Transplantation”. RESTORTM Program – University of Pittsburgh, Pittsburgh, Pennsylvania. US Army Institute of Surgical Research, Joint Base San Antonio (Fort Sam Houston, Lackland Base, Randolph Base), Texas. NATO CSO-HFM-272 SYMPOSIUM, Brussels, Belgium, October 17-20, 2016.

Raval, S.B., Zhao, T., Krishnamurthy, N., Santini, T.R., Gorantla, V.S., Ibrahim, T.S., “Upper extremity neural and vascular imaging with UHF 7T MRI,” Podium presentation in Proc. of The 23rd International Society of Magnetic Resonance in Medicine Annual Meeting, Toronto, Canada, May 2015. Proceedings, Presentation

Raval, S.B., Zhao, T., Zhao, Y., Gorantla, V.S., Ibrahim, T.S., “Ultrahigh field MRI after upper extremity transplantation”, in Podium presentation in Proc. of The 23rd International Society of Magnetic Resonance in Medicine Annual Meeting, Toronto, Canada, May 2015. Proceedings, Presentation

Krishnamurthy, N., Zhao, Y., Kim, J-H., Raval, S.B., Zhao T., Ibrahim, T.S. “T2* Susceptibility Weighted and Echo- Planar Imaging at 7T using RF Shimming” in Proc. of The 23rd International Society of Magnetic Resonance in Medicine Annual Meeting, Toronto, Canada, May 2015.

Ibrahim, T.S., Santini, T.R., Raval, S.B., Krishnamurthy, N., Wood, S., Kim, J-H., Zhao, T., Wu, X.S., Yacoub, E.S., Aizenstein, H.J., Zhao, T., “Towards Homogeneous 7T neuro Imaging and Comparisons between 7T TTT and NOVA RF Coil Systems”, in Proc. of The 25th International Society of Magnetic Resonance in Medicine Annual Meeting, Honolulu, April 2017. Proceedings, Presentation

Krishnamurthy, N., Zhao, Y., Raval, S.B., Kim, J-H., Wood, S., Santini, T.R., Zhao, T., Ibrahim, T.S., “7T Multi-Slab Whole-Head Homogenous and Low SAR T2 Acquisitions” in Proc. of The 23rd International Society of Magnetic Resonance in Medicine Annual Meeting, Toronto, Ontario, MayJune 2015. Proceedings, Presentation

Schirda, C., Zhao, T., Raval, S.B., Lee, S., Arslanian, S., Hetherington, H.P., Ibrahim, T.S., “Functional 2D 31P MRSI in the leg during exercise, using a dual-tuned 1H/31P volume coil” in Proc. of The 23rd International Society of Magnetic Resonance in Medicine Annual Meeting, Toronto, Ontario, May-June 2015. Proceedings, Presentation

Wood, S., Santini, T.R., Krishnamurthy, N., Raval, S.B., Ibrahim, T.S., “Evaluation of Anthropomorphic phantom with In-vivo using Quantitative MRI”, in Proc. of The 25th International Society of Magnetic Resonance in Medicine Annual Meeting, Honolulu, April 2017. Proceedings, Presentation

Wood, S., Krishnamurthy, N., Zhao, Y., Raval, S.B., Zhao, T., Holmes, J.A., Ibrahim, T.S. “Anatomically Detailed Human Head Phantom for MR”, in Proc. of The 22nd International Society of Magnetic Resonance in Medicine Annual Meeting, Milan, May 2014. Proceeding, Presentation

Zhao, Y., Krishnamurthy, N., Wood, S., Zhao, T., Raval, S.B., Ibrahim, T.S., “3D eigenmodes optimizations for 3D imaging at 7T” in Proc. of The 23rd International Society of Magnetic Resonance in Medicine Annual Meeting, Toronto, Ontario, May-June 2015. Proceedings, Presentation

Krishnamurthy, N., Zhao, Y., Maccloud, R., Zhao, T., Raval, S.B., Kim, J., Rosano, C., Aizenstein, H.J., Ibrahim, T.S. “Segmentation of Small Veins Using 3D isotropic SW images at 7T” in Proc. of The 22nd International Society of Magnetic Resonance in Medicine Annual Meeting, Milan, May 2014. Proceedings, Presentation

Krishnamurthy, N., Wood, S., Kim, J-H., Zhao, Y., Raval, S.B., Zhao, T., Ibrahim, T.S. “Transmit Array Performance across Subjects at 7T MRI: Simulations and Experiments” in Proc. of The 22nd International Society of Magnetic Resonance in Medicine Annual Meeting, Milan, May 2014.

Ibrahim, T.S., Zhao, Y., Krishnamurthy, N., Raval, S.B., Zhao, T., Wood, S., Kim, J-H., “20-to-8 Chanel Tx Array with 32 channels adjustable receive-only insert for 7T Head Imaging”, in Proc. of The 21st International Society of Magnetic Resonance in Medicine Annual Meeting, Utah, May 2013. Proceedings, Presentation

Krishnamurthy, N., Zhao, Y., Kim, J-H., Raval, S.B., Zhao, T., Ibrahim, T.S. “7T Multi-Slab WholeHead Homogenous and Low SAR T2 Acquisitions” Pittsburgh Imaging Community Retreat – Mellon Institute CMU, Pittsburgh, May 2014.

Zhao, Y., Zhao, T., Wood, S., Krishnamurthy, N., Raval, S.B., Kim, J-H., Ibrahim, T.S., “3D SAR Constrained Homogeneous B1+ Field at 7T” in Proc. of The 21st International Society of Magnetic Resonance in Medicine Annual Meeting, Utah, May 2013.

Krishnamurthy, N., Raval, S.B., Zhao, Y., Wood, S., Zhao, T., Ibrahim, T.S., “Experiment and Simulation Validation of the effect of 32 Channel Receive Array Inserts on Transmit B1+ and SAR at 7Tesla Parallel Transmit System” in Proc. of The 21st International Society of Magnetic Resonance in Medicine Annual Meeting, Utah, May 2013.

Santini, T.R., Krishnamurthy, N., Wood, S., Raval, S.B., Zhao, Y., Fischetti, A., Koo, M., Aizenstein, H.J., Ibrahim, T.S., 64-channel Double-Octagon Tx Head Coil for 7T Imaging, in Proc. of The 25th International Society of Magnetic Resonance in Medicine Annual Meeting, Honolulu, April 2017. Proceedings,

Ibrahim, T.S., Santini, T.R., Raval, S.B., Krishnamurthy, N., Wood, S., Kim, J.H., Zhao, T., Wu, X.S., Yacoub, E.S., Aizenstein, H.J., Zhao, T.S. Towards Homogeneous 7T neuro Imaging and Comparisons between 7T TTT and NOVA RF Coil Systems, in Proc. of The 25th International Society of Magnetic Resonance in Medicine Annual Meeting, Honolulu, April 2017. Proceedings, Presentation

Krishnamurthy, N., Zhao, Y., Raval, S.B., Kim, J-H., Wood, S., Santini, T., Zhao, T., Ibrahim, T.S., 7T Multi-Slab Whole-Head Homogenous and Low SAR T2 Acquisitions in Proc. of The 23rd International Society of Magnetic Resonance in Medicine Annual Meeting, Toronto, Ontario, May-June 2015. Proceedings, Presentation

Krishnamurthy, N., Zhao, Y., Kim, J-H., Raval, S.B., Zhao, T., Ibrahim, T.S., T2* Susceptibility Weighted and Echo- Planar Imaging at 7T using RF Shimming in Proc. of The 23rd International Society of Magnetic Resonance in Medicine Annual Meeting, Toronto, Canada, May 2015.

Krishnamurthy, N., Zhao, Y., Maccloud, R., Zhao, T., Raval, S.B., Kim, J-H., Rosano, C., Aizenstein, H.J., Ibrahim, T.S. Segmentation of Small Veins Using 3D isotropic SW images at 7T in Proc. of The 22nd International Society of Magnetic Resonance in Medicine Annual Meeting, Milan, May 2014, Proceedings, Presentation

Krishnamurthy, N., Wood, S., Kim, J., Zhao, Y., Raval, S.B., Zhao, T., Ibrahim, T.S., Transmit Array Performance across Subjects at 7T MRI: Simulations and Experiments in Proc. of The 22nd International Society of Magnetic Resonance in Medicine Annual Meeting, Milan, May 2014

Zhao, Y., Zhao, T., Wood, S., Krishnamurthy, N., Raval, S.B., Kim, J-H., Ibrahim, T.S., 3D SAR Constrained Homogeneous B1+ Field at 7T, in Proc. of The 21st International Society of Magnetic Resonance in Medicine Annual Meeting, Utah, May 2013.

Ibrahim, T.S., Zhao, Y., Zhao, T., Krishnamurthy, N., Wood, S., Raval S.B., Kim, H., 20-to-8 Channel Tx Array with 32-channel Adjustable Receive-Only Insert for 7T Head Imaging. in The 21st International Society of Magnetic Resonance in Medicine Annual Meeting. 2013. Salt Lake City, Utah, USA, Proceedings, Presentation

Ibrahim, TS., Hue, Y-k., Boada, F.E., Gilbert, R., Tic-Tac-Toe: Highly-Coupled, Load Insensitive Tx/Rx Array and a Quadrature Coil without Lumped Capacitors. Proc. in The 16th International Society of Magnetic Resonance in Medicine Annual Meeting & Exhibition 2008, North America, USA, Proceedings

Ibrahim, T.S., Zhao, T., Jefferies, E., Zheng, H., Boada, F.E., 5 Decoupled Sets of Coupled Coils: An 8-20 Channel Subject-Insensitive Array for 7T Applications. Proc. in The 18th International Society of Magnetic Resonance in Medicine Annual Meeting & Exhibition 2010, Stockholm, Sweden, Proceedings, Presentation

Raval, S.B., Zhao, T., Krishnamurthy, N., Ibrahim, T.S., Gorantla, V.S., “Ultra-high field upper extremity peripheral nerve and non-contrast vascular imaging at 7T Tesla high resolution MRI”, in Proc. Of the International hand and Composite Tissue Allotransplantation Society Annual Meeting, USA.

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